Journal Guide

RNA serves as an international forum for publishing original reports on RNA research in the broadest sense. The journal aims to unify this field by cutting across established disciplinary lines and focusing on "RNA-centered" science.RNA is a monthly journal which provides rapid publication of significant original research in all areas of RNA structure and function in eukaryotic, prokaryotic, and viral systems. It covers a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; mRNA structure, function and biogenesis; alternative processing: cis-acting elements and trans-acting factors; ribosome structure and function; translational control; RNA catalysis; tRNA structure, function biogenesis and identity; RNA editing; rRNA structure, function and biogenesis; RNA transport and localization; regulatory RNAs; large and small RNP structure, function and biogenesis; viral RNA metabolism; RNA stability and turnover; in vitro evolution; and RNA chemistry.RNA considers papers in six categories: Reports, Articles, Bioinformatics, Hypotheses, Methods, and Letters to the Editor. Reports document significant new results that lend themselves to succinct presentation (i.e., combined Results and Discussion) and can contain no more than four display items. Reports are evaluated using the same criteria as Articles; preliminary observations that require further experimentation to support the major conclusions will not be accepted. There are no explicit length limitations to Articles and length is not a criterion for evaluation. Bioinformatics describe computer-based analyses of sequence data or new informatic tools of interest to RNA scientists. Hypotheses outline novel concepts or new ways of integrating existing data. Methods are brief accounts of methodological advances or improvements that are of potential utility to a broad range of RNA researchers. Letters to the Editor are intended as a forum for raising or clarifying issues of specific interest to the RNA community.In addition to the categories above, RNA publishes Reviews, Perspectives, Mini-reviews, and Meeting Summaries. Normally, these are by invitation, but presubmission inquiries to the Reviews Editor are welcome.This journal is published by CSHL Press for RNA Society. Authors are not required to be members of the Society. Queries regarding editorial policies or manuscripts in review should be directed to the Editorial Office at rnajournal@case.edu.Subscription to the print journal includes full access to the online edition at http://www.rnajournal.org. (Online-only subscriptions are available to institutions.) A subscription to RNA is included with RNA Society membership. For more information about RNA Society and membership, visit RNA Society.

C. elegans RDE-4 is a double-stranded RNA binding protein that has been shown to play a key role in response to foreign double-stranded RNA (dsRNA). We have used diverse tools for analysis of gene function to characterize the domain and organismal foci of RDE-4 action in C. elegans. First, we examined the focus of activity within the RDE-4 protein, by testing a series of RDE-4 deletion constructs for their ability to support dsRNA-triggered gene silencing. These assays indicated a molecular requirement for a linker region and the second dsRNA-binding domain of RDE-4, with ancillary contributions to function from the C and N terminal domains. Second, we used mosaic.

Robotics and Automation, Mechatronics, Artificial Intelligence (incl. Robotics), Control, Computational Intelligence

At the heart of open access for the global chemistry community. RSC Advances publishes advances in chemistry, and in topics of interest to the chemistry community.

RSC Applied Interfaces is a dedicated, interdisciplinary reference journal for cutting-edge research on the applications of surfaces and interfaces. In addition to the applied focus, work considered for publication in RSC Applied Interfaces is expected to be highly original and of top quality. Research papers should highlight the role of interfaces (morphology and composition) and interfacial processes in determining a material’s properties and functionalities. The journal seeks to report major scientific advances beyond the state of the art, at the cutting edge of this interdisciplinary field. Our RSC Applied journals are dedicated to materials science research with a strong focus on innovation in the application, and sit alongside Journals of Materials Chemistry A, B and C in terms of quality and impact.

RSC Applied Polymers is a leading international journal for the application of polymers, including experimental and computational studies on both natural and synthetic systems. The journal is a premier cross-disciplinary publishing home for scientific research that leverages polymeric materials in a range of applications, welcoming high-impact advances made possible with polymers across materials, biology, energy applications, and beyond. Polymer researchers across chemistry, materials science, biology, and engineering, are all welcome to share timely and impactful contributions, connecting fundamental scientific insights to performance-related metrics. The journal welcomes research on the application of polymers in different areas, and the relationship to structure and/or composition, as afforded by synthesis and/or processing. Our RSC Applied journals are dedicated to materials science research with a strong focus on innovation in the application, and sit alongside Journals of Materials Chemistry A, B and C in terms of quality and impact.

RSC Chemical Biology is a gold open access journal dedicated to publishing and disseminating exceptional, breakthrough research and high-quality reviews at the interface of chemistry and biology. We welcome contributions from across the breadth of the chemical biology field. This includes Sensing and Imaging, Bioorthogonal chemistry, Biosynthesis, Biomimetics and Bioengineering, Synthetic biology, Directed evolution, Drugs development and mechanism of action, Glycoscience, Natural products, Nucleic acids, Peptides, Phenotypic screening, Proteins (including protein-protein interactions, modifications, structure and function) We are particularly interested in reports on the application of chemical tools to probe, explore and visualize biological systems and processes to provide insights into molecular mechanisms in health and disease. We also encourage translational research that bridges chemistry and chemical biology to medicine.

RSC Mechanochemistry focuses on the publication of innovative research that advances the fundamental understanding and application of the use of mechanical force for driving and controlling chemical reactions and materials transformations in the gas, liquid, and solid states. As mechanochemistry is where chemistry and mechanics meet, and involves the interaction of mechanical energy with matter at the molecular, supramolecular, and bulk materials levels, it encompasses not only areas such as sustainable chemical synthesis, but also tribochemistry, chemo/mechanical transduction (e.g. polymer mechanochemistry, mechano-biology, photo-mechanochemistry), and mechanical alloying. Submissions on all aspects related to mechanochemistry and its role in enhancing and broadening sustainable chemistry are welcome.

RSC Medicinal Chemistry publishes significant research in medicinal chemistry and related drug discovery science. Research articles published in RSC Medicinal Chemistry must show a breakthrough or significant advance on previously published work, or bring new thinking or results that will have a strong impact in their field. Topics within the journal's scope include, but are not limited to: design, synthesis and biological evaluation of novel chemical entities or biotherapeutic modalities; modifications of known chemical entities or biotherapeutic modalities that result in a significantly greater understanding of their structure-activity relationships, an improvement of their properties or provide other information of significant value; novel methodologies and technologies in the broader chemical and biological sciences; computational, machine learning and artificial intelligence (AI) studies are welcome where they significantly advance medicinal chemistry knowledge; studies that examine the effect of the molecular structure of a compound on pharmacokinetic behaviour and pharmacodynamics; studies that present new insights into drug design based on analysis of existing experimental datasets or new theoretical approaches if supported by experimental evidence; studies presenting new drug delivery systems with novel chemical agents are welcomed, in particular those that involve chemical modification of the delivery system of conjugation with novel delivery vectors.

RSC Pharmaceutics is a new gold open access journal leading the way in the field of Pharmaceutics. This journal publishes research focused on formulating a drug into a medicine, with the intention of achieving controllable drug delivery with high efficacy. Research published in RSC Pharmaceutics promotes step-change science in the field of Pharmaceutics, and, as such, all submissions must show clear innovation, be scientifically sound, and have a significant impact on the field. Research sharing new scientific findings from across the areas of chemistry, materials science, biomedical sciences, pharmaceutics and drug delivery are all welcomed. Topics include but are not limited to: • Formulation and design of medicines • Design and characterization of correct dosage forms • Physicochemical and biological properties of drugs and their carriers • Drug delivery devices and their mechanisms of release

RSC Sustainability welcomes all solutions-focused research dedicated to solving sustainability challenges. This includes, but is not limited to, technologies to achieve responsible consumption and production of chemical products (UN’s SDG:12), such as for the efficient use of nature’s resources, the elimination of hazardous substances in the production and use of chemical products (sustainable and green chemistry), their reuse and recycling (circular economy) and methods to analyse these (techno-enviro-economics). Beyond this, RSC Sustainability champions chemical science discoveries that contribute to and enable any of the UN’s Sustainable Development Goals, celebrates multidisciplinary collaboration, and welcomes work from the academic, industry, regulatory and government sectors.