Journal Guide

Mutagenesis is an international multi-disciplinary journal designed to bring together research aimed at the identification, characterization and elucidation of the mechanisms of action of physical, chemical and biological agents capable of producing genetic change in living organisms and the study of the consequences of such changes.

Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis broadly encompasses all aspects of research that address the detection of mutations, the mechanisms by which mutations in genes and chromosomes arise, and the modulation of mutagenesis by mutation avoidance pathways such as DNA repair, cell cycle control and apoptosis. It includes the role of genetic variation in the genesis and manifestation of mutations, ranging from the variable manner in which xenobiotics are metabolized to variations in the capacity of cells to replicate and repair damaged DNA. It also includes the contributions of these mechanisms, when perturbed, to animal disease models and to human disease, with particular emphasis on carcinogenic mechanisms. The Journal will publish articles on the genesis of aneuploidy and isodisomy, including the roles played by recombination, cell cycle checkpoints, spindle microtubules, centrosomes and kinetocore proteins, and agents that might disrupt them. Submission of appropriate epidemiological studies as well as consequences, including methods for high throughput SNP detection, whole genome and exonic sequencing, DNA microarrays, RNAseq approaches and proteomics are welcome. Submission of preliminary epidemiological studies that associate SNPs with a phenotype but provide no mechanistic insight is discouraged. The broader scope of the journal is a reflection of the rapid advances in the field of mutation research and the recognition that understanding of the mutagenic process requires full knowledge of the cellular response to DNA damage including DNA repair, cell cycle checkpoint arrest and apoptosis.Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com

Mutation Research - Genetic Toxicology and Environmental Mutagenesis publishes papers advancing knowledge in the field of genetic toxicology. Papers are welcomed in the following areas:New developments in genotoxicity testing of chemical agents (e.g. improvements in methodology of assay systems and interpretation of results).Alternatives to and refinement of the use of animals in genotoxicity testing.Nano-genotoxicology, the study of genotoxicity hazards and risks related to novel man-made nanomaterials.Studies of epigenetic changes in relation to genotoxic effects.The use of structure-activity relationships in predicting genotoxic effects.The isolation and chemical characterization of novel environmental mutagens.The measurement of genotoxic effects in human populations, when accompanied by quantitative measurements of environmental or occupational exposures.The application of novel technologies for assessing the hazard and risks associated with genotoxic substances (e.g. OMICS or other high-throughput approaches to genotoxicity testing).Mutation Research - Genetic Toxicology and Environmental Mutagenesis is now accepting submissions for a new section of the journal that will be dedicated to the discussion of current issues relating to design, interpretation and strategic use of genotoxicity tests (Current Topics in Genotoxicity Testing). This section is envisaged to include discussions relating to the development of new international testing guidelines, but also to wider topics in the field. The evaluation of contrasting or opposing viewpoints is welcomed as long as the presentation is in accordance with the journal's aims, scope, and policies.Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com

The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection andfunctional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.Genetic toxicology and environmental mutagenesis (including the factors that modulate the genetic activity of environmental agents) will continue to be prominent topics in this section. In addition to full-length reviews, mini-reviews on specific topical themes will be published.Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com